Carbon dioxide reforming of methane (CRM) (or dry reforming) to synthesis gas has received great attention in the past two decades. Synthesis gas, a mixture of H2 and CO, is an important feedstock for several chemical processes operated in the production of methanol and synthetic fuels through a Fischer-Tropsch synthesis. The process has great potential in converting methane and carbon dioxide (two major greenhouse gases) into synthesis gas as shown by reaction CH4 + CO2 = 2CO + 2H2. This reaction plays a potentially important role in industry in generating synthesis gas with a low H2/CO ratio that can be preferentially used for the production of liquid hydrocarbons in the Fischer Tropsch synthesis. Thermodynamic calculations indicate that there is also a potential for the formation of carbon. Dry reforming reaction is accompanied by several side reactions. The most important reactions are the reverse water–gas shift reaction. So far, the CH4-CO2 reforming has been studied over numerous supported metal catalysts including Ni-based catalysts as well as noble metal-based ones. In this project, CRM was investigated in a fixed bed reactor using γ-Al2O3, Al2MgO4 (Al2O3-MgO) supported Co-Ni and Cu-Ni based catalysts with varying Co (1 - 15 wt %), Cu (1 - 6 wt %) and 10% Ni loadings were prepared using impregnation and sonochemical methods. The catalysts prepared from sonochemical method are usually Nano-sized particle. Nano-sized particle catalysts showed better catalytic activity as compared with conventional catalysts and are promising for the CH4-CO2 reforming. All prepared catalysts were characterized with BET analysis, X-ray diffraction (XRD), SEM, TEM, H2-TPR and H2-TPD techniques. The performances of all the synthesized catalysts were tested at a pressure of 1 atm, and temperatures of 600 - 900 °C in a laboratory pilot for CO2 Reforming of Methane.